How many parameters can I control using a DASGIP or DASbox system?

DASGIP Parallel Bioreactor Systems provide comprehensive concurrent monitoring and control of process parameters. During the process run, events are logged together with up to 70 online process variables per bioreactor. In addition to the various DASGIP modules for monitoring and control, with DASware analyze users can integrate analytical devices provided by third parties. Seamless integration into the DASGIP or DASbox system even allows for closed loop solutions such as automated feeding strategies based on the current glucose concentration. Each process value can be used as a trigger enabling users to automate their process.

How many parameters can be displayed in a process overview in DASware control?

DASware control users can freely select all relevant process variables of all or selected bioreactors to be displayed in one chart. There are no limitations in the number of process parameters. When using DASware analyze, the displayed process parameters even include integrated data from third party laboratory devices, such as nutrient analyzers, mass spectrometers or Raman. The software features tables and trend graphs of all measured values. It continuously logs and stores all data and events. These data are immediately accessible for evaluation using e.g. Microsoft Excel. Advanced charting functionalities ease further data analysis and comparison of runs.

Do I need programming skills to automate my process in DASware control?

DASware control includes a set of easy to implement automation features without any need of programming. Profiles and triggers allow for various control strategies, all of them easy to select by mouse click with parameters entered manually or just copy-pasted. Users with programming skills and special control requirements, however, are free to run scripted control strategies and profiles as well.

Can I change triggers, profiles, cascades and scripts online in DASware control?

Set-points, profiles, cascades, and scripts are online editable in DASware control. Offline values and events can be entered during or after the run and documented with a time stamp. These time stamps can be set individually, e.g to meet the time, when the sample was taken. This provides users with great flexibility to interact with the control system and reconsider parameter settings even in highly automated processes. All events, including online changes, are recorded in a SQL Server database.

How are DASGIP vessels agitated?

DASGIP bioreactors feature powerful overhead drives with agitation speeds ranging 30 – 1,600 rpm. The DASGIP TC4SC4 controls temperature and agitation in up to four bioreactors. Users can individually define each outlet set-point as well as choose from different operation modes (e.g. continuous or interval agitation).

Does DASware control give any alarms in case of critical deviation?

Critical deviation of process parameters such as pH, DO, redox, and temperature are color-coded in the software and saved in the event log. DASware control professional additionally allows notification of supervisory control systems or mobile communication tools via SMS or e-mail.

Can you help adjusting my controller loop parameters in DASware control?

DASGIP controllers are PI controllers, which are configured with default controller parameters adapted to the type of vessel and default experimental requirements. Depending on special customer requirements it might be necessary to modify these parameters. Our service will be happy to help you finding the right settings.

How to calibrate a pH sensor in DASware control?

DASware control software allows for parallel calibration of all sensors used within one system with all data logged in the central database together with set-points, profiles, cascades, process values, user interactions and other events. Good maintenance will prolong the sensors' lifetime whereas high temperatures (i.e. during autoclavation), alkaline solutions (i.e. during alkaline deactivation), repeated etchings and improper maintenance will reduce the electrode's lifetime.

How reliable are exhaust data when working at benchtop scale?

Exhaust oxygen and carbon dioxide concentrations of multiple bioreactor units are continuously monitored with the DASGIP GA exhaust analyzer. Together with the mass flow measurement and the input values of oxygen and carbon dioxide concentrations, automatic calculation of oxygen transfer rate (OTR), carbon dioxide transfer rate (CTR), and respiratory quotient (RQ) is possible, permitting direct conclusions on the metabolic state of a culture. As the DASGIP GA considers humidity, volume, and total flow typical sources for inaccurate OTR and CTR data in small working volumes are eliminated.

Is it possible to automatically control the foam in DASGIP vessels?

All DASGIP vessels can be equipped with foam control components. All you need is a level/foam sensor connected to the DASGIP sensor module (e.g. PH4PO4L) and a feed line for dosing of the antifoam agent. Now foam formation can be detected by the level sensor and antifoam agent is automatically pumped into the vessel until all foam is collapsed. The DASware control software allows any feed line to be used for antifoam or level control. Since medium composition has a strong impact on the electrical conductivity of medium and foam, every conductivity-based level sensor needs to be adjusted to foam and medium conductivity. DASware control supports monitoring conductivity and free adjustment of the conductivity threshold.

What maintenance is required for Eppendorf bioprocess systems?

As all complex technical systems Eppendorf bioprocess equipment should be maintained regularly to keep all parts in good condition. This maintenance avoids cost-intensive down times and contributes to preservation of value. A complete preventive maintenance is recommended once a year. Additional maintenance actions are recommended to be executed by the user prior to every run or in regular cycles (e.g. every month). Our service will be happy to advice.

What do I have to consider when returning equipment for repair?

Equipment returned to Eppendorf for service or any other reason needs to be decontaminated first. Please fill out the Decontamination Form that you will find in the “Service & Support” section of the Eppendorf website and attach it to the package. Equipment which was sent without the completely filled form cannot be handled. This form must also be completed before any on-site service, whether covered under warranty or not, can commence.

What does your warranty cover?

Eppendorf issues a warranty of one year from the day of delivery on its products in accordance with our terms and conditions. Excluded are consumables such as cables, tubing, glassware, and sensors as well as used material.

Does Eppendorf offer bioreactor training?

We highly recommend a training at the customer’s site for all new customers. Besides this initial training, Eppendorf also offers individual trainings adapted to the user’s requirements like training of new employees or advanced training/recapitulation for employees already having experience with DASGIP or DASbox systems. All trainings are performed at the customer’s site using the customer’s equipment to have the training focused on the customer’s demands. The structure and methods of the training can be chosen to the customer’s requirements from general overview to detailed sessions on specific products or issues. Training in small groups is as possible as personal guidance.

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DASbox^® Mini Bioreactor System

BioBLU c and BioBLU f Single-Use Bioreactors for small and bench scale cell culture, stem cell, and fermentation applications.

製品情報

The DASbox Mini Bioreactor System is a parallel bioreactor system for research and process development in small working volumes. It can operate up to 24 glass or BioBLU^® Single-Use Bioreactors in parallel and is suitable for microbial fermentation and cell culture, including the cultivation of stem cells. With working volumes from 60 mL to 250 mL it is an optimal tool for efficient process development, Design of Experiments (DoE) approaches, and scale-down applications.

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製品情報

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特徴

Small scale. Big results.

The DASbox Mini Bioreactor System enables highly efficient process development by allowing precise control of critical process parameters, rapid comparison of numerous experimental conditions, reduction of medium costs, and optimal utilization of all generated data.
• Small working volumes save resources.
• Parallel operation of up to 24 bioreactors saves time and space and improves reproducibility.
• Easily convertible from single-use to reusable bioreactors and vice versa.
• DASware^® software suite enables precise monitoring and control of critical process parameters, as well as the implementation of tailored feedback loops, feeding strategies and other features.
• Seamless integration with the Bioprocess Autosampler allows for automated sampling 24/7 to gain complete datasets.
• Connects to BioNsight^® cloud software for remote process monitoring and simple, remote analysis of all data sets to make informed decisions.

Operate small bioreactors in parallel

• The DASbox Mini Bioreactor System is designed as a 4-fold system that is expandable to up to 24 parallel operating bioreactors.
• A 24-fold DASbox system takes up only 1.8 m (6 ft) of bench space. This corresponds to 7.5 cm (3 in) per vessel.
• The setpoints, control strategies, and inoculation time of each bioreactor can be controlled individually from one software installation. Like this, multiple experimental conditions can be tested in parallel, for example in a Design of Experiments (DoE) approach.

Automate bioprocess sampling

• The DASbox system can be seamlessly integrated with the Bioprocess Autosampler, which takes samples from multiple bioreactors 24/7 in short and regular intervals and stores them tempered for later analysis.
• The Bioprocess Autosampler can be installed with new as well as retrofitted to existing bioreactor control systems.

Cultivate various cell types, including stem cells

• The DASbox is a unique mini bioreactor system suitable for microbial and cell culture as well as stem cell applications.
• Glass and single-use bioreactor variants are available, which are optimized to support the special needs of stem cells, such as low-shear mixing and aggregate formation.

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仕様	DASbox^® 胞培養	DASbox^® 胞培養シングルユース	DASbox^® Microbiology	DASbox^®微生物研究シングルユース

アプリケーション	細胞培養	細胞培養	微生物研究用	微生物研究用
パラレルユニット数	最大24	最大24	最大24	最大24
ソフトウェア	DASwareコントロール、その他のDASwareオプション	DASwareコントロール、その他のDASwareオプション	DASwareコントロール、その他のDASwareオプション	DASwareコントロール、その他のDASwareオプション
ユーザーインターフェース	プロセスコンピューター、モニター付き	プロセスコンピューター、モニター付き	プロセスコンピューター、モニター付き	プロセスコンピューター、モニター付き
代表的な消費電力（プロセスコンピュータなしの4倍システム）	168 W （ 230 V）/ 154 W （ 115 V）	168 W （ 230 V）/ 154 W （ 115 V）	168 W （ 230 V）/ 154 W （ 115 V）	168 W （ 230 V）/ 154 W （ 115 V）
寸法（W × D × H、プロセスコンピュータなしの4倍システム）	30 x 70 x 49 cm (12 x 28 x 19 in)	30 x 70 x 49 cm (12 x 28 x 19 in)	30 x 70 x 49 cm (12 x 28 x 19 in)	30 x 70 x 49 cm (12 x 28 x 19 in)
製品の重量	44 kg	44 kg	44 kg	44 kg
平均重量	44 kg	44 kg	44 kg	44 kg
細菌、酵母、菌類	はい	はい	はい	はい
哺乳類/動物	はい	はい	はい	はい
昆虫	はい	はい	はい	はい
差し替え可能容器	はい	はい	はい	はい
検証可能な	いいえ	いいえ	いいえ	いいえ
幹細胞	はい	はい	はい	はい

バイオリアクター
チューブ	ガラス容器	シングルユース容器	ガラス容器	シングルユース容器
滅菌	オートクレーブ可能	滅菌済み	オートクレーブ可能	滅菌済み
総容量	350mL	380mL	350mL	380mL

撹拌
ドライブ	ダイレクトオーバーヘッドドライブ	磁力オーバーヘッドドライブ	ダイレクトオーバーヘッドドライブ	磁力オーバーヘッドドライブ
速度範囲	20 – 2500 rpm	20 – 500 rpm	20 – 2500 rpm	20 – 2000 rpm
撹拌羽根	マリーン	ピッチブレード	Rushton型	Rushton型

ガス供給
ガス供給	TMFC; オーバーレイおよび/または噴霧器	TMFC; オーバーレイおよび/または噴霧器	TMFC; 噴霧器	TMFC; 噴霧器
標準ガス流量	0.04 – 5 sL/h、0.04 – 3.5 sL/h CO₂	0.04 – 5 sL/h、0.04 – 3.5 sL/h CO₂	0.2 – 25 sL/h、0.2 – 18 sL/h CO₂	0.2 – 25 sL/h、0.2 – 18 sL/h CO₂
標準ガス混合	空気、N₂、O₂および/またはCO₂	空気、N₂、O₂および/またはCO₂	空気、N₂、O₂および/またはCO₂	空気、N₂、O₂および/またはCO₂

Feeding
容器あたりの供給ライン	2 （標準）/ 4 （オプション）	2 （標準）/ 4 （オプション）	2 （標準）/ 4 （オプション）	2 （標準）/ 4 （オプション）
標準フィード速度の範囲は（チューブ径に応じて）	0.3 – 9.5 mL/h～13 – 420 mL/h	0.3 – 9.5 mL/h～13 – 420 mL/h	0.3 – 9.5 mL/h～13 – 420 mL/h	0.3 – 9.5 mL/h～13 – 420 mL/h

モニタリングおよび制御
温度制御	クーラント不要の加熱および冷却装置（ペルチェ式）	クーラント不要の加熱および冷却装置（ペルチェ式）	クーラント不要の加熱および冷却装置（ペルチェ式）	クーラント不要の加熱および冷却装置（ペルチェ式）
標準温度範囲 (25 ° C 室温)	10 – 60°C	10 – 45°C	10 – 60°C	10 – 45°C
pH制御	CO₂/ベースおよびその他セットアップ	CO₂/ベースおよびその他セットアップ	酸あるいは塩基その他のセットアップ	酸あるいは塩基その他のセットアップ
DO制御	段階的制御（O_2濃度、ガス流量）、その他の設定	段階的制御（O_2濃度、ガス流量）、その他の設定	段階的制御（撹拌速度、O_2濃度、ガス流量）、その他の設定	段階的制御（撹拌速度、O_2濃度、ガス流量）、その他の設定
ORP (還元) センサー	-	-	オプション（Redoxまたはレベルを選択）	オプション（Redoxまたはレベルを選択）
レベル/フォーム	オプション	オプション	オプション（Redoxまたはレベルを選択）	オプション（Redoxまたはレベルを選択）
OD測定	オプション (DASGIP OD4)	オプション (DASGIP OD4)	オプション (DASGIP OD4)	オプション (DASGIP OD4)
Exhaust Condensation	クーラント不要（ペルチェ式）	クーラント不要（ペルチェ式）	クーラント不要（ペルチェ式）	クーラント不要（ペルチェ式）
排気分析	-	-	オプション (DASGIP GA4)	オプション (DASGIP GA4)

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