The BioFlo 320 is highly configurable to suit your requirements
The BioFlo 320 offers the highest level of application flexibility, made possible by features like universal connections for analog and digital sensors, up to six integrated pumps, a highly configurable gas flow control, and compatibility with a wide range of glass and single-use bioreactors.
• Suitable for the cultivation of human and animal cells, including stem cells, as well as microbial fermentation.
• Supports batch, fed-batch, continuous, and perfusion mode.
• Suitable for many applications, including the production of cells, secreted proteins, viral vectors, plasmids, and small molecules.
The BioFlo 320 seamlessly connects R&D to production
The BioFlo 320 is compatible with a wide selection of glass and single-use bioreactors, providing working volumes from 400 mL to 40 L on a single platform. In combination with the BioFlo 720 bioreactor control system, the BioFlo platform supports one of the widest range of single-use solutions, allowing the scale-up of your process to up to 2,000 L.
• Integrated Scale Up Assist software feature simplifies the calculation of important process parameters necessary to scale up and down.
• Validation packages are available for GMP-regulated processes.
• Emerson® DeltaV integration with the BioFlo 320 simplifies tech-transfer, scale-up, and recipe sharing.
Integrated software assistants save time and mitigate risks
Monitoring the controller and the process is key to successful process development. The BioFlo 320 software is designed to provide you with the status of both.
• Alarm functions automatically inform about the status of the process.
• The diagnostic screen provides information on the hardware status and upcoming maintenance.
• Auto Calibrate – automatic calibration of all connected DO sensors at once reduce preparation time and ensures consistency.
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BioFlo® 320
BioFlo 320 controller only close up
BioFlo 320 with BioBLU 50c and scale
The BioFlo 320 is compatible with 250 mL - 40 L BioBLU Single-Use Bioreactors.
BioFlo 320 3 units
BioFlo 320 pump detail
Easy-load pump heads provide quick installation of the pump tubing.
BioFlo 320 with cell culture vessel and scale
BioFlo-320-vessels 600-1500mL, with motor
BioFlo 320 with cell culture glass and single-use vessel
A compact design, available in left- and right-handed orientation makes the BioFlo 320 the smarter solution for your laboratory.
BioFlo 320 microbiology workflow
BioFlo 320 mirror set up cell culture and fermentation
The Smarter Solution
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Product Information
The BioFlo 320 is a universal controller for bioprocessing at bench scale. It is suitable for cell culture as well as fermentation applications and can be used with glass and BioBLU® Single-Use Bioreactors. Powerful technology for precise process monitoring and control, a large working volume range, and software features that save time and reduce risks make it a reliable partner for developing robust processes and moving them from R&D to production.You will find additional download material at the bottom of this page
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Product Information
Applications
Features
Product Information
Intelligent Sensors
• Integrated Mettler Toledo Intelligent Sensor Management (ISM) platform
• Universal connections for up to four analog or digital (ISM) sensors
• pH: analog or digital (ISM)
• DO: analog or digital (ISM)
• Optical DO: digital (ISM)
• Redox: analog or digital (ISM)
• CO2: digital (ISM)
• Real-time sensor diagnostics anticipate sensor failure
Advanced Software Solutions
• Control eight units from a single user interface
• Automatic gas mixing algorithms for simplified control (4-gas, 3-gas)
• O2 enrichment, N2 enrichment
• Ten-point cascade feature for sophisticated control strategies
• Built-in elapsed fermentation timer for batch management
• Trend display with up to twelve process values within a single view
• Remote access via PC or tablet
Small footprint
From R&D laboratories to pilot-scale production facilities, space is an important factor when selecting the right equipment. The BioFlo 320 offers flexibility, better control, and maximum functionality while occupying a fraction of the valuable lab space of similar systems. This means greater efficiency and productivity at a lower operating cost for your lab.
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Applications
- Universal bench-scale controller for cell culture and fermentation applications
- Fermentation of aerobic and anaerobic bacteria, yeasts, and fungi
- Cultivation of mammalian, insect, and human cell lines
- Cultivation of stem cells
- Specialized packed-bed impeller for the cultivation of anchorage and non-anchorage dependent cells, for example for vaccine process development
- Cell culture on microcarriers using specialized cell-lift impeller
- Suitable for batch, fed-batch, and continuous/perfusion processes
Features
- Universal control for both microbial and cell culture applications
- Controls up to eight systems from a single user interface
- Interchangeable autoclavable and BioBLU Single-Use Bioreactors
- Up to six integrated pumps capable of operating in variable-speed mode
- Integrated Mettler Toledo® ISM® platform
- Built-in optical pH sensing technology for use with the BioBLU Single-Use Bioreactors
- Field-upgradable TMFC drawers for sparge and overlay gas
- Eight independently controlled process gas supplies
- Enhanced software package with new cascade and time profile features
- DeltaV compatibility available through DeltaV Discovery and DeltaV ProPlus PAS
- Validation packages available for GMP-regulated processes
- Compatible with DASware Software Suite or BioCommand for bioprocess information management
