The BioFlo 120 is designed to support scientists in bioprocess R&D with flexibility and ease of use.
• Compatible with a variety of autoclavable glass and BioBLU Single-Use Bioreactors.
• Scalability from 250 mL to up to 40 L.
• Sensitive mammalian cells as well as high-demand microbial cultures can be processed on a single controller.
• Auto Culture software feature for an easy start.
• Requires minimal installation time.
• Saves valuable lab space with a minimal footprint.
• Compatible with DASware® software suite and BioNsight® cloud for advanced process control, and remote process monitoring and data analysis, respectively.
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BioFlo® 120
BioFlo 120 advanced control station
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BioFlo 120 Cell culture top view
BioFlo 120 Auto Culture mode
The BioFlo 120 Auto Culture modes allow 1-touch process control for microbial and cell culture applications.
BioFlo 120 Fermentation row
BioFlo 120 Fermentation close up
BioFlo 120 Fermentation touchscreen
Product Information
The BioFlo 120 is a bench-scale controller for bioprocess R&D. It is suitable for cell culture as well as fermentation applications and can be used with glass vessels and BioBLU® Single-Use Bioreactors. It offers simplicity and ease of use, no matter if you are in an academic, governmental or industrial research setting.BioFlo 120
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Product Information
Technical Data
Applications
Features
Product Information
Auto Culture Mode
• In Auto Culture mode, process control loop modes and setpoints are automatically turned on and populated with values recommended by our experienced applications development team.
• The Auto Culture mode allows users, who are less familiar with bioreactors and fermentors, to achieve quick and easy initial culture success on which they can build on.
• Can serve as starting point for optimization: All setpoints and modes of operation can be adjusted, optimized, and saved as user-defined recipes.
Intelligent sensors
• Integrated Mettler Toledo® Intelligent Sensor Management (ISM®) platform.
• Universal connections for up to two analog or digital (ISM) sensors.
• pH: analog or digital (ISM)
• DO: analog or digital (ISM)
• Optical DO: digital (ISM)
• Redox: analog or digital (ISM)
• CO2: digital (ISM)
Gas flow control
• High-precision expanded-range thermal mass flow controller provides the capability for low flow mammalian cell culture through high-demand microbial processes on a single controller.
• Standard automatic mixing of four independent sparge gas supplies.
• Three ranges of TMFC options available as well as manual rotameter option
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Technical Data
| Specifications | BioFlo 120 |
|---|
| Number of parallel units | Single unit |
| Communication | 2 × USB (software updates, serial communication) Ethernet (SCADA, IP Network) |
| User Interface | 7 in projected capacitive touchscreen |
| Power supply | 100 – 120/208 – 240 V ±10 %, 50/60 Hz |
| Dimensions (W × D × H) | 24.7 × 55.9 × 62.9 cm / 9.7 × 22.0 × 24.8 in |
| Product weight | 14.8 kg / 32.7 lb |
| Bacteria/Yeast/Fungi | yes |
| Mammalian/Animal | yes |
| Insect | yes |
| Interchangeable Vessels | yes |
| Validatable | no |
| Stem cells | yes |
| Water supply | Quick-connect; 10 psig (0.69 barg) |
| Power supply | IEC-C14 (with regional plug types); 100 – 120/208 – 240 (±10 %) V, 50/60 Hz, 10 A, Single Phase |
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Bioreactors |
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| Vessels | Glass/single-use vessels |
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Gassing |
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| Gas supply | Push-connect fittings accept 1/4 in tubing or hose barb fitting; Autoclavable vessels: 10 psig (0.69 barg), Single-use vessels: 6 psig (0.44 barg) |
| Max. gas flow rates | 20 SLPM |
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Monitoring and Control |
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| Exhaust condensation | Water-cooled or Electric heater band |
Applications
- Cultivation of mammalian cells, stem cells, and insect cells
- Bacterial, yeast, and fungal fermentation
- Suitable for batch, fed-batch, and continuous/perfusion processes
Features
- Scale-up from 250 mL to 40 L on a wide variety of autoclavable and Eppendorf BioBLU Single-Use Bioreactors.
- Auto culture modes offer process control for microbial and cell culture applications at the touch of a button.
- Ready for process. Unbox and install in minutes.
- Save critical lab space with a minimal footprint.
- Flexible universal connections for analog sensors or digital Mettler Toledo® ISM sensors offer unsurpassed flexibility.
- User-defined DO cascades offer process flexibility.
- Automatic gas mixing algorithms for simplified control.
- View your entire process with expanded trend screen.
- Compatible with DASware® software suite for advanced bioprocess information management.
- Remote data access through VNC connection to the touchscreen controller or BioNsight® cloud software.
