CelliGen 510

The CelliGen 510 is a compact sterilizable-in-place cell culture system ideal for pilot to small scale production processes. The modular design features a wide variety of standard options allowing this system to be flexible enough to meet most process requirements.
Gas flow
• Various combinations of one, two, three or four TMFCs:
0.06  –   3 SLPM
0.3  –   15 SLPM
0.6  –   32 SLPM
1  –   64 SLPM
• Air Wash System with TMFC (0  – 15 or 0  –  32 SLPM)
• Overlay with TMFC (0 –  15 or 0  – 32 SLPM)
• Overlay (valve only)

Exhaust line
• Exhaust condenser
• Manual or automatic pressure control

Impellers
• Rushton-type – Used commonly for robust cell lines such as bacteria, yeasts, and algae, where maximum OTR is desired.
• Pitched-blade – Commonly used with mammalian, insect or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial and radial mixing. Provided as standard with the CelliGen 510 bioreactors.
• Marine – Commonly used with mammalian, insect, or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial mixing
• Spinfilter – For suspension or microcarrier cultures where a dip tube inside the filter withdraws cell media as harvest or waste
• Cell-Lift – Specially designed to provide uniform circulation for both suspension and microcarrier cultures. Can be used with optional decanting columns for perfusion cultures
• Packed-bed – For secreted products from anchorage-dependent and suspension cells, this impeller immobilizes cells in a bed of Fibra-Cel^® Disks to provide extremely high cell densities

Sensors
• Single or redundant pH/DO
• Redox
• Foam/level

Addition and sampling
• Resterilizable sampling valve
• Resterilizable addition valves (4 max)
• Resterilizable addition/harvest valve with dip tube (2 max)
• 1.5 in sanitary fitting 7-port septum
• Addition vessels (glass/stainless steel)
• Decanters
• Sterile sampling assembly

Validation
• Basic Package
• Basic Plus Package
• Enhanced Package

Utility regulator & pre-filter kits
• Process air pre-filter/regulator kit
• Instrument air pre-filter/regulator kit
• Water pre-filter/regulator kit
• Process steam regulator kit
• Utility steam pre-filter/regulator kit
• Utility connection kit

Additional options
• Sprayballs for clean-in-place of vessel
• External variable-speed pumps
• External scales
• Spare parts kits
• Preventative maintenance kits
• Mobile table
• System passivation
• Glycol/chiller heat exchanger