DASbox® Mini Bioreactor System
产品信息
The DASbox Mini Bioreactor System is a parallel bioreactor system for research and process development in small working volumes. It can operate up to 24 glass or BioBLU® Single-Use Bioreactors in parallel and is suitable for microbial fermentation and cell culture, including the cultivation of stem cells. With working volumes from 60 mL to 250 mL it is an optimal tool for efficient process development, Design of Experiments (DoE) approaches, and scale-down applications.您可以在以下网址找到其他下载资料本页面底部
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产品信息
技术数据
用途
特征
产品信息
The DASbox Mini Bioreactor System enables highly efficient process development by allowing precise control of critical process parameters, rapid comparison of numerous experimental conditions, reduction of medium costs, and optimal utilization of all generated data.
• Small working volumes save resources.
• Parallel operation of up to 24 bioreactors saves time and space and improves reproducibility.
• Easily convertible from single-use to reusable bioreactors and vice versa.
• DASware® software suite enables precise monitoring and control of critical process parameters, as well as the implementation of tailored feedback loops, feeding strategies and other features.
• Seamless integration with the Bioprocess Autosampler allows for automated sampling 24/7 to gain complete datasets.
• Connects to BioNsight® cloud software for remote process monitoring and simple, remote analysis of all data sets to make informed decisions.
Operate small bioreactors in parallel
• The DASbox Mini Bioreactor System is designed as a 4-fold system that is expandable to up to 24 parallel operating bioreactors.
• A 24-fold DASbox system takes up only 1.8 m (6 ft) of bench space. This corresponds to 7.5 cm (3 in) per vessel.
• The setpoints, control strategies, and inoculation time of each bioreactor can be controlled individually from one software installation. Like this, multiple experimental conditions can be tested in parallel, for example in a Design of Experiments (DoE) approach.
Automate bioprocess sampling
• The DASbox system can be seamlessly integrated with the Bioprocess Autosampler, which takes samples from multiple bioreactors 24/7 in short and regular intervals and stores them tempered for later analysis.
• The Bioprocess Autosampler can be installed with new as well as retrofitted to existing bioreactor control systems.
Cultivate various cell types, including stem cells
• The DASbox is a unique mini bioreactor system suitable for microbial and cell culture as well as stem cell applications.
• Glass and single-use bioreactor variants are available, which are optimized to support the special needs of stem cells, such as low-shear mixing and aggregate formation.
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技术数据
规格 | DASbox® 细胞培养 | DASbox® 细胞培养一次性反应器 | DASbox®微生物培养 | DASbox® 微生物培养一次性反应器 |
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应用 | 细胞培养 | 细胞培养 | 微生物发酵 | 微生物发酵 |
平行控制罐体数量 | 最多 24 个 | 最多 24 个 | 最多 24 个 | 最多 24 个 |
软件 | DASware 控制器,其他 DASware 选配 | DASware 控制器,其他 DASware 选配 | DASware 控制器,其他 DASware 选配 | DASware 控制器,其他 DASware 选配 |
用户界面 | 带监测系统的生物过程计算机 | 带监测系统的生物过程计算机 | 带监测系统的生物过程计算机 | 带监测系统的生物过程计算机 |
典型能耗(4 罐体系统,无过程电脑) |
168 W ( 230 V)/ 154 W ( 115 V) |
168 W ( 230 V)/ 154 W ( 115 V) |
168 W ( 230 V)/ 154 W ( 115 V) |
168 W ( 230 V)/ 154 W ( 115 V) |
尺寸(W × D × H,4 罐体系统,无过程电脑) |
30 x 70 x 49 cm (12 x 28 x 19 in) |
30 x 70 x 49 cm (12 x 28 x 19 in) |
30 x 70 x 49 cm (12 x 28 x 19 in) |
30 x 70 x 49 cm (12 x 28 x 19 in) |
产品重量 | 44 kg | 44 kg | 44 kg | 44 kg |
常规重量 | 44 kg | 44 kg | 44 kg | 44 kg |
细菌/酵母菌/真菌 | 是 | 是 | 是 | 是 |
哺乳动物/动物 | 是 | 是 | 是 | 是 |
昆虫 | 是 | 是 | 是 | 是 |
可互换罐体 | 是 | 是 | 是 | 是 |
可验证 | 否 | 否 | 否 | 否 |
干细胞 | 是 | 是 | 是 | 是 |
生物反应器 |
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罐体 | 玻璃罐体 | 一次性罐体 | 玻璃罐体 | 一次性罐体 |
灭菌 | 高温高压灭菌 | 预先灭菌 | 高温高压灭菌 | 预先灭菌 |
总体积 | 350 mL | 380 mL | 350 mL | 380 mL |
搅拌 |
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驱动 | 顶部直联驱动 | 顶部磁力驱动 | 顶部直联驱动 | 顶部磁力驱动 |
速度范围 | 20 – 2500 rpm | 20 – 500 rpm | 20 – 2500 rpm | 20 – 2000 rpm |
搅拌桨 | 螺旋搅拌桨 | 斜叶桨 | 平叶桨 | 平叶桨 |
通气 |
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供气 | TMFC;表层通气及(或)气体分布器 | TMFC;表层通气及(或)气体分布器 | TMFC;气体分布器 | TMFC;气体分布器 |
标配气体流量 | 0.04 – 5 sL/h,0.04 – 3.5 sL/h CO2 | 0.04 – 5 sL/h, 0.04 – 3.5 sL/h CO2 | 0.2 – 25 sL/h, 0.2 – 18 sL/h CO2 | 0.2 – 25 sL/h, 0.2 – 18 sL/h CO2 |
标准气体混合 | 空气、N2、O2和/或CO2 | 空气、N2、O2和/或CO2 | 空气、N2、O2和/或CO2 | 空气、N2、O2和/或CO2 |
补料 |
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每个罐体的补料线 |
2条 (标配)/ 4条 (选配) |
2条 (标配)/ 4条 (选配) |
2条 (标配)/ 4条 (选配) |
2条 (标配)/ 4条 (选配) |
标准补料速度(取决于管直径) | 0.3 – 9.5 mL/小时至于13 – 420 mL/小时 | 0.3 – 9.5 mL/小时至于13 – 420 mL/小时 | 0.3 – 9.5 mL/小时至于13 – 420 mL/小时 | 0.3 – 9.5 mL/小时至于13 – 420 mL/小时 |
监测及控制 |
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温度控制 | 无水加热或制冷( Peltier ) | 无水加热或制冷( Peltier ) | 无水加热或制冷( Peltier ) | 无水加热或制冷( Peltier ) |
标准温度范围(在 25° C 室温下) | 10 – 60°C | 10 – 45°C | 10 – 60°C | 10 – 45°C |
pH 控制 | CO2 / 碱液和其他设置 | CO2 / 碱液和其他设置 | 酸液和(或)碱液和其他设置 | 酸液和(或)碱液和其他设置 |
DO 控制 | 级联控制(O2 浓度,气体流量)及其他设置 | 级联控制(O2 浓度,气体流量)及其他设置 | 级联控制(搅拌速度、O2 浓度、气体流量)及其他设置 | 级联控制(搅拌速度、O2 浓度、气体流量)及其他设置 |
ORP (redox) 测量 | - | - | 可选(选择氧化还原或液位电极) | 可选(选择氧化还原或液位电极) |
液位/泡沫 | 可选 | 可选 | 可选(选择氧化还原或液位电极) | 可选(选择氧化还原或液位电极) |
OD 监测 |
可选 (DASGIP OD4 模块) |
可选 (DASGIP OD4 模块) |
可选 (DASGIP OD4 模块) |
可选 (DASGIP OD4 模块) |
尾气冷凝器 | 无水冷凝(Peltier) | 无水冷凝(Peltier) | 无水冷凝(Peltier) | 无水冷凝(Peltier) |
尾气分析 | - | - |
可选 (DASGIP GA4 模块) |
可选 (DASGIP GA4 模块) |
用途
- Process development in cell culture and microbiology
- Controlled cultivation of stem cells
- Design of Experiments (DoE)
- Media optimization
- Clone and cell line screening, strain characterization
特征
- Parallel set-up of up to 24 bioreactors
- Excellent scalability and reproducibility in both microbial and cell culture applications
- Supports industry standard glass bioreactors (DASbox Mini Bioreactor) as well as BioBLU 0.3 Single-Use Bioreactors
- Small working volumes save on the amount of cell material, medium and supplements required
- Extremely compact system with a footprint of only 7.5 cm (3 in) benchspace per vessel
- Individual temperature control with liquid-free heating and cooling (Peltier)
- Liquid-free Peltier exhaust condenser with easy handling by automatic slide in activation and slide out deactivation mode
- LC display with key process parameters and integrated alarm function simplifies monitoring
- Fully mass flow-controlled gas mixing with individual gas mixture from air, N2, O2, and CO2, each directable either to headspace or sparger
- Standard sensors for precise measurement and control of temperature, pH, DO, level and ORP (redox potential); optical pH sensors available
- Precise miniature variable speed pumps, continuous flow rates down to 0.3 mL/h
- Sealed magnetic overhead drives for single-use vessels and direct overhead drives for autoclavable vessels; up- or downflow selectable
- Optional pull-out system for enhanced accessibility of bioreactors and control unit