How many parameters can I control using a DASGIP or DASbox system?

DASGIP Parallel Bioreactor Systems provide comprehensive concurrent monitoring and control of process parameters. During the process run, events are logged together with up to 70 online process variables per bioreactor. In addition to the various DASGIP modules for monitoring and control, with DASware analyze users can integrate analytical devices provided by third parties. Seamless integration into the DASGIP or DASbox system even allows for closed loop solutions such as automated feeding strategies based on the current glucose concentration. Each process value can be used as a trigger enabling users to automate their process.

How many parameters can be displayed in a process overview in DASware control?

DASware control users can freely select all relevant process variables of all or selected bioreactors to be displayed in one chart. There are no limitations in the number of process parameters. When using DASware analyze, the displayed process parameters even include integrated data from third party laboratory devices, such as nutrient analyzers, mass spectrometers or Raman. The software features tables and trend graphs of all measured values. It continuously logs and stores all data and events. These data are immediately accessible for evaluation using e.g. Microsoft Excel. Advanced charting functionalities ease further data analysis and comparison of runs.

Do I need programming skills to automate my process in DASware control?

DASware control includes a set of easy to implement automation features without any need of programming. Profiles and triggers allow for various control strategies, all of them easy to select by mouse click with parameters entered manually or just copy-pasted. Users with programming skills and special control requirements, however, are free to run scripted control strategies and profiles as well.

Can I change triggers, profiles, cascades and scripts online in DASware control?

Set-points, profiles, cascades, and scripts are online editable in DASware control. Offline values and events can be entered during or after the run and documented with a time stamp. These time stamps can be set individually, e.g to meet the time, when the sample was taken. This provides users with great flexibility to interact with the control system and reconsider parameter settings even in highly automated processes. All events, including online changes, are recorded in a SQL Server database.

How difficult is it to modify a DASGIP system subsequently?

Due to the unique modular design of the DASGIP Parallel Bioreactor System upgrades and modifications can easily be done: Functions like OD monitoring, exhaust analysis or extra feed lines can be added as modules to the control system. It is just as easy to substitute the bioreactor type or to upgrade a 4-vessel system to eight vessels. Actually, system modifications are that simple, some customers even share specific modules. For instance, the DASGIP GA4 exhaust analyzer is renowned for being moved from one bioreactor system to another. Like this, it delivers reliable in-depth analysis of OTR, CTR, and RQ for many bioreactors on demand.

How many speed-controlled pumps do the DASGIP bioreactors feature?

Up to eight peristaltic speed-controlled pumps per vessel offer continuous flow rates from 0.3 mL/h - 5 L/h. Each pump can be operated independently. Two different pump head sizes for the multi pump modules DASGIP MP4 and MP8, fitting various tube sizes make the DASGIP multi pumps a flexible and accurate solution.

How are DASGIP vessels agitated?

DASGIP bioreactors feature powerful overhead drives with agitation speeds ranging 30 – 1,600 rpm. The DASGIP TC4SC4 controls temperature and agitation in up to four bioreactors. Users can individually define each outlet set-point as well as choose from different operation modes (e.g. continuous or interval agitation).

Can I integrate DASGIP with my existing historians & supervisory control?

Yes, with the software DASware connect an optional server allows corporate-wide exchange of all process data via seamless integration with historians and supervisory control systems such as Delta V, OSI Pi, etc. This includes events, set-up information, and system status.

How can I harness data generated by the DASGIP system?

With DASware control all data and events are logged in one central SQL Server database. Further features such as export into Excel, PDF, and other file formats via one mouse click and strong charting capabilities ease plotting and data analysis. To harness data from numerous projects, on the long-run advanced archiving capabilities and data retrieval is required. DASware discover offers comprehensive and user-defined archiving functions and data retrieval for powerful data comparison and analysis. Users can, for example, link the utilized strain or cell line with its media composition, the controller setpoints and feeding profiles as well as with achieved product yields or viable cell densities to select for the best optimized combination and process.

Does DASware control give any alarms in case of critical deviation?

Critical deviation of process parameters such as pH, DO, redox, and temperature are color-coded in the software and saved in the event log. DASware control professional additionally allows notification of supervisory control systems or mobile communication tools via SMS or e-mail.

Can you help adjusting my controller loop parameters in DASware control?

DASGIP controllers are PI controllers, which are configured with default controller parameters adapted to the type of vessel and default experimental requirements. Depending on special customer requirements it might be necessary to modify these parameters. Our service will be happy to help you finding the right settings.

How to calibrate a pH sensor in DASware control?

DASware control software allows for parallel calibration of all sensors used within one system with all data logged in the central database together with set-points, profiles, cascades, process values, user interactions and other events. Good maintenance will prolong the sensors' lifetime whereas high temperatures (i.e. during autoclavation), alkaline solutions (i.e. during alkaline deactivation), repeated etchings and improper maintenance will reduce the electrode's lifetime.

How reliable are exhaust data when working at benchtop scale?

Exhaust oxygen and carbon dioxide concentrations of multiple bioreactor units are continuously monitored with the DASGIP GA exhaust analyzer. Together with the mass flow measurement and the input values of oxygen and carbon dioxide concentrations, automatic calculation of oxygen transfer rate (OTR), carbon dioxide transfer rate (CTR), and respiratory quotient (RQ) is possible, permitting direct conclusions on the metabolic state of a culture. As the DASGIP GA considers humidity, volume, and total flow typical sources for inaccurate OTR and CTR data in small working volumes are eliminated.

Is it possible to automatically control the foam in DASGIP vessels?

All DASGIP vessels can be equipped with foam control components. All you need is a level/foam sensor connected to the DASGIP sensor module (e.g. PH4PO4L) and a feed line for dosing of the antifoam agent. Now foam formation can be detected by the level sensor and antifoam agent is automatically pumped into the vessel until all foam is collapsed. The DASware control software allows any feed line to be used for antifoam or level control. Since medium composition has a strong impact on the electrical conductivity of medium and foam, every conductivity-based level sensor needs to be adjusted to foam and medium conductivity. DASware control supports monitoring conductivity and free adjustment of the conductivity threshold.

What maintenance is required for Eppendorf bioprocess systems?

As all complex technical systems Eppendorf bioprocess equipment should be maintained regularly to keep all parts in good condition. This maintenance avoids cost-intensive down times and contributes to preservation of value. A complete preventive maintenance is recommended once a year. Additional maintenance actions are recommended to be executed by the user prior to every run or in regular cycles (e.g. every month). Our service will be happy to advice.

What do I have to consider when returning equipment for repair?

Equipment returned to Eppendorf for service or any other reason needs to be decontaminated first. Please fill out the Decontamination Form that you will find in the “Service & Support” section of the Eppendorf website and attach it to the package. Equipment which was sent without the completely filled form cannot be handled. This form must also be completed before any on-site service, whether covered under warranty or not, can commence.

What does your warranty cover?

Eppendorf issues a warranty of one year from the day of delivery on its products in accordance with our terms and conditions. Excluded are consumables such as cables, tubing, glassware, and sensors as well as used material.

Does Eppendorf offer bioreactor training?

We highly recommend a training at the customer’s site for all new customers. Besides this initial training, Eppendorf also offers individual trainings adapted to the user’s requirements like training of new employees or advanced training/recapitulation for employees already having experience with DASGIP or DASbox systems. All trainings are performed at the customer’s site using the customer’s equipment to have the training focused on the customer’s demands. The structure and methods of the training can be chosen to the customer’s requirements from general overview to detailed sessions on specific products or issues. Training in small groups is as possible as personal guidance.

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DASGIP^® 병렬 바이오리액터 시스템

DASGIP Parallel Bioreactor System for Microbiology Bioblock

제품 정보

Eppendorf DASGIP Parallel Bioreactor Systems은 소규모 구성에서 최상의 Bioprocess 성능을 보장합니다. 확장형 모니터링 및 제어 기능으로 사용자가 경제적인 방식으로 유효하고 재현 가능한 결과를 도출할 수 있습니다. 모듈형 디자인으로 다양한 Cell Culture 및 미생물 실험의 고유한 요구사항을 충족합니다.

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세포 배양과 미생물 실험의 R&D 및 프로세스 개발을 위한 DASGIP Parallel Bioreactor Systems은 고급 바이오프로세스 제어 및 자동화를 지원합니다 병렬 프로세싱, 모든 관련 파라미터의 정밀 제어, 사용자 정의 프로필 그리고 다양한 자동화 기능으로 프로세스 개발 속도와 효율이 향상됩니다. DASware 소프트웨어 솔루션은 DoE(Design of Experiments), 프로세스 히스토리언 및 종합적인 데이터 관리를 지원합니다. Eppendorf의 원심분리 솔루션은 미생물, 포유류 및 인간 세포, 줄기세포 실험 그리고 생체 연료 및 생체 고분자 프로세스의 특수한 요구조건을 충족합니다.

사양	Cell Culture용 DASGIP^® 시스템	미생물 실험용 DASGIP^® 시스템

용도	Cell Culture	미생물
병렬 유닛 수	최대 16개	최대 16개
소프트웨어	DASware control, 기타 DASware 옵션	DASware control, 기타 DASware 옵션
사용자 인터페이스	모니터가 장착된 프로세스 컴퓨터	모니터가 장착된 프로세스 컴퓨터
일반 소비 전력(4단 시스템, 프로세스 컴퓨터 미포함)	480 W (230 V)/ 432 W (115 V) ( DASGIP Bioblock이 없을 경우 595 W/552 W)	541 W (230 V)/ 467 W (115 V) (639 W/584 W, DASGIP Bioblock 미포함)
치수(W × D × H, 4단 시스템, 프로세스 컴퓨터 미포함)	140 x 70 x 53 cm (55 x 28 x 21 in)	140 x 70 x 53 cm (55 x 28 x 21 in)
일반 무게	78 kg (DASGIP Bioblock이 없을 경우 60 kg)	96 kg (DASGIP Bioblock이 없을 경우 78 kg)
박테리아/효모/균류	예	예
포유류/동물	예	예
곤충	예	예
교체형 Vessel	예	예
검증성	아니요	아니요
줄기 세포	예	예

Bioreactor
Vessel	유리/일회용 Vessel	유리/일회용 Vessel
멸균	오토클레이브/ 사전 멸균	오토클레이브/ 사전 멸균
총 용량	1.5 L - 2.3 L	1.3 L - 2.1 L

교반
드라이브	다이렉트/마그네틱 오버헤드 드라이브	다이렉트/마그네틱 오버헤드 드라이브
속도 범위	30 – 1,250 rpm (기본사항)/ 100 – 1,600 rpm (선택사항)	100 – 1,600 rpm (기본사항)/ 30 – 1,250 rpm (선택사항)
임펠러	피치 블레이드	Rushton 타입

기체 주입
기체 공급	TMFC; 오버레이 및/또는 스파저	TMFC/로터미터; 스파저
표준 기체 유량	0.1 – 50 sL/h, 0.1 – 40 sL/h CO₂ (DASGIP MX4/4, 다른 모듈 사용 가능)	0.5 – 250 sL/h, 0.5 – 150 sL/h CO₂ (DASGIP MX4/4H, 다른 모듈 사용 가능)
표준 기체 Mixing	Air, N₂, O₂ 및/또는 CO₂	Air, N₂, O₂ 및/또는 CO₂

공급
Vessel당 공급 라인	최대 8대	최대 8대
표준 공급 속도(튜브 직경에 따라 다름)	0.3 – 9.5 mL/h - 13 – 420 mL/h (DASGIP MP8) 10 – 70 mL/h - 0.4 – 5 L/h (DASGIP MP4)	0.3 – 9.5 mL/h - 13 – 420 mL/h (DASGIP MP8) 10 – 70 mL/h - 0.4 – 5 L/h (DASGIP MP4)

모니터링 및 제어
온도 제어	DASGIP Bioblock에 가열 및 냉각 기능 통합(추가 냉각 핑거 옵션)	DASGIP Bioblock에 가열 및 냉각 기능 통합(추가 냉각 핑거 옵션)
표준 온도 범위(25° C 실온)	냉매 온도 – 99°C 이상에서 5 K (DASGIP Bioblock)¹⁾	냉매 온도 – 99°C 이상에서 5 K (DASGIP Bioblock)¹⁾
pH 제어	−	산 및/또는 염기, 및 기타 셋업
DO 제어	캐스케이드(O₂ 농도, 기체 유량) 및 기타 셋업	캐스케이드(교반 속도, O₂ 농도(선택사항), 기체 유량(선택사항)) 및 기타 셋업
ORP (redox) 측정	-	선택사항
레벨/거품	선택사항	선택사항
OD 측정	선택사항 (DASGIP OD4)	선택사항 (DASGIP OD4)
배기 응축	수냉식 또는 무액체(Peltier 및 DASGIP EGC4)	수냉식 또는 무액체(Peltier 및 DASGIP EGC4)
배기 분석	선택사항 (DASGIP GA4)	선택사항 (DASGIP GA4)
1)작업별 작동 온도 적용