What does the term 2DMix-Control technology describe/stand for?

2DMix-Control technology describes the ability of the MixMate, ThermoMixer C and ThermoMixers F to mix small sample volumes in various plate and tube formats quickly and in a controlled manner. To achieve this, the interplay of all crucial factors for efficient and controlled mixing, have been optimized. And these are: - Generation of sufficient mixing energy: due to an orbital mixing movement at a high mixing speed and a relatively large mixing radius (1.5 mm) the devices generate enough mixing energy (analogous to g-force in centrifuges) to mix even the smallest volumes efficiently. - Minimized loss of mixing energy: special attention was paid to reducing inherent vibration. Smooth operation combined with reliable stability ensures that all the mixing energy is available for mixing and not wasted through transmission of vibrations to the device or its surroundings. - Controlled transmission of energy from the device to the sample: Minimizing vertical movements enable a plane, 2-dimensional (2D) mixing stroke. This, in conjunction with the reliable plate and tube holders and SmartBlocks, prevents uncontrolled chaotic movements and allows all formats to be held securely, even at high mixing frequencies.

Which cleaning and disinfection agents can be recommended for cleaning and disinfection of ThermoMixer C, ThermoMixer F and ThermoStat C?

Switch off the device, disconnect the mains/power plug and make sure that no liquid can get into the inside of the housing. When cleaning has been completed, the device should only be connected when it is fully dry on the inside and on the outside. Use lint-free cloth and soft bottle brush or cotton swabs for SmartBlocks and SmartExtender. Do not use any aggressive chemicals on the device or its accessories such as strong and weak bases, strong acids, acetone, formaldehyde, halogenated hydrocarbons or phenol. If the device is contaminated with aggressive chemicals, clean it immediately using a mild cleaning agent and wipe it off with dist. water afterwards. Recommended cleaning agents: mild, soap-based lab cleaner dist. water Recommended disinfectants: ethanol (70%) isopropanol (70%) Please follow the detailed safety instructions in the Operating Manual.

Is the housing of ThermoMixer C, ThermoMixer F and ThermoStat C stable against UV irradiation?

A disinfection by UV irradiation cannot be recommended, because discoloration of the housing materials can occur.

Which DNA and RNAse deconatmination agents can be recommended for decontamination of the devices and the SmartBlocks?

We tested DNA away and RNase away and we can recommend to use both agents.

Are start and end position of the SmartBlocks the same?

No. Start and end position are not identical.

How can the temperature accuracy be verified?

The best possible temperature accuracy can be guaranteed by individually adjusting a SmartBlock. Optimized temperature control for each block type keeps temperature overshoots and deviations caused by external interferences to a minimum. To guarantee optimal performance over the entire period of use, Eppendorf offers a preventive maintenance program and certification services: your Eppendorf ThermoMixers, ThermoStat C as well as the SmartBlocks are regularly cleaned, checked and adjusted. Additional information is available at: https://www.eppendorf.com/epservices . Customers can also verify the temperature accuracy by themself. Eppendorf provides for that purpose the Temperature Verification System – Single Well for Eppendorf Mastercyclers (0056 000.003) in combination with the 384 well Sensor (0056 002.006).

Can cell culture plates be used in the SmartBlock plates?

Also cell cultuture plates can be used in the SmartBlock plates in so far the dimensions of the plate comply to the SBS standard.

Is it possible to run more than one program in automatic succession on a ThermoMixer or ThermoStat C?

No. Each program has to be chosen and run separately. But the 4 possible steps within a program run in automatic succession.

Which SmartBlocks and vessels can be used with ThermoMixers F?

The ThermoMixers F possess a fix installed SmartBlock and can only be used with the appropriate microtest tubes or plates, such as MTP’s, DWP’s or skirted plates complying the SBS standard. For using PCR plates our SmartBlocks PCR 96 and PCR 384 in combination with ThermoMixer C is the proper choice.

Can PCR plates be used in SmartBlock plates respectively ThermoMixer FP?

SmartBlock plates and ThermoMixer FP (with the fixed SmartBlock plates) are dedicated for using MTP’s, DWP’s and also other skirted plates which meet the SBS standard. For optimal usage of PCR plates the SmartBlock PCR 96 and PCR 384 in combination with ThermoMixer C or ThermoStat C is the proper choice. These SmartBlocks possess conical bores which surround the conical wells of PCR plates properly for a perfect temperature transition.

Why should I have my ThermoMixer serviced at regular intervals?

Eppendorf Performance Plans offer a selection of preventive maintenance services which ensure a consistent performance of the device and confidence in the results.

How often does my ThermoMixer need to be serviced?

This depends on how intensively it is used and varies depending on the load on the device. However, we recommend to have it serviced at least once a year.

What do you need to look out for before carrying out a service?

The device needs to be decontaminated first. The device must be freely accessible and all samples removed from the device. You should also ensure that the device has cooled down already.

What types of service programs are available for the ThermoMixer?

The available service programs can be found under the respective instrument in the Service & Support / Maintenance and Certification Services section.

What are the costs for the different ThermoMixer service programs?

The cost depends on the model and on the service that is performed. Please contact your local Eppendorf Service.

Please contact your local Eppendorf Service Team. You find the contact data on our homepage or in the information materials.

What is IQ or OQ and what do I need them for?

Installation and operational qualification; the IQ documents that the device has been delivered and installed correctly. The OQ checks the correct functioning of a device. IQ/OQ ensure that your quality management requirements are met and that your device operates properly and in accordance with the manufacturer’s specifications.

How often does the OQ need to be carried out for a ThermoMixer?

The company is responsible for technical checks of devices. Eppendorf recommends regular device qualifications depending on the intensity of use, however, they should be carried out at least once a year.

What does the temperature verification include and how often does it need to be carried out?

To ensure that your ThermoMixer delivers reproducible and correct results, temperature verification and adjustment - if required - are strongly recommended. Temperature verification is a very accurate and precise method and complies with all laboratory requirements with regard to documentation and detection in accordance with national and international standards.

How can temperature accuracy be verified?

The best temperature accuracy possible is ensured by the individual adjustment of each SmartBlock. The Eppendorf Temperature Verification System- Single Channel is used to check the temperature accuracy of the thermoblock. In combination with the temperature sensor for the Eppendorf ThermoMixer, the exact temperature in the thermoblock can be measured. You can find further information in the corresponding operating manual.

How can my device be cleaned and which cleaning agents and disinfectants can be used for cleaning and disinfection of ThermoMixer C, ThermoMixer F and ThermoStat C?

Switch off the device, disconnect the mains/power plug and make sure that no liquid can get into the inside of the housing. When cleaning has been completed, the device should only be connected when it is fully dry on the inside and on the outside. Do not use any aggressive chemicals on the device or its accessories such as strong and weak bases, strong acids, acetone, formaldehyde, halogenated hydrocarbons or phenol. If the device is contaminated with aggressive chemicals, clean it immediately using a mild cleaning agent. Use a lint-free cloth and a mild, soapy laboratory cleaner and distilled water. Clean the housing and the thermoblock regularly. Please refer to your operating manual for further information - Maintenance chapter

What types of training or online training do you offer to enable me to improve my skills?

Please visit the Eppendorf webpage about the Eppendorf Training Center or contact your local Eppendorf Service for further information and a quotation.

Is it possible to use the Eppendorf Thermomixer for 24 h and at 7 days?

Yes, this is possible. The customer has just to set the time to endless.

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Eppendorf ThermoMixer^® C

Eppendorf ThermoMixer and MixMate family

Eppendorf ThermoMixer C with broad range of SmartBlocks for different vessel types

Eppendorf ThermoMixer C with ThermoTop for safe sample incubation

Eppendorf ThermoMixer C with ThemoTop for enhanced temperature accuracy and less condensation within sample tubes

Mixing a low-volume sample within a 96 well plate

Eppendorf ThermoMixer_C with SmartBlock_15 mL_for sample heating and mixing

Eppendorf ThermoMixer_C with SmartBlock_PCR 96_for incubating PCR plates

An Eppendorf ThermoMixer heats/cools/shakes also larger vessels

ThermoMixer C SmartBlock: plate, total, angle

Eppendorf ThermoMixer C with SamrtBlock and lid

Eppendorf SmartBlock removal by pressing the lever (Step 1)

Eppendorf SmartBlock removal by pressing the lever (Step 2)

Eppendorf SmartBlock removal by pressing the lever (Step 3)

Eppendorf Transfer_Rack_1.5/2.0 mL_to transfer samples from Eppendorf ThermoMixer C

Eppendorf ThermoMixer C with lab scientist who puts 96 well plate on SmartBlock

Eppendorf ThermoMixer C with lab scientist who changes the ThermoTop

ThermoMixer C SmartBlock: 1.5mL, total, front

ThermoMixer C SmartBlock: plates, total, front

ACT label of sustainability certification for Eppendorf ThermoMixer C

Product Information

Eppendorf ThermoMixer C is for heating, cooling, and mixing of almost any of your lab vessels. Reliable prevention of condensate formation in small vessels can be achieved with the heated lid Eppendorf ThermoTop (optional).

Show more Product Information

Learn more about sustainability at Eppendorf - incl. how to recognize a sustainable thermomixer instrument

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You will find additional download material at the bottom of this page

Products (1)

epServices (10)

Accessories (19)

VisioNize (2)

1 Products

Eppendorf ThermoMixer^® C

basic device without thermoblock
ACT, 220 – 240 V/50 – 60 Hz (EU)

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Catalog no. 5382000015

Price

3.123,00 €

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Product Information

Technical Data

Applications

Features

You need everything? The Eppendorf ThermoMixer C combines excellent mixing performance with excellent temperature control to ensure complete, dependable and reproducible test results. Improve your assay results by mixing and incubating samples at the same time. The Eppendorf ThermoMixer C convinces users with its quick and easy-to-exchange SmartBlocks for all common lab vessels, new and improved program functions, and high level of stability for every mixing frequency. There is almost no limit to the variety of applications waiting for you!

Facing irregular mixing results?

Reliable sample mixing is far beyond simple mixing, especially when talking about microliter volumes. After decades of offering mixing devices, we found a way to expand reliable mixing performance to the microliter scale:

^2DMix-Control

The ^2DMix-Control technology mixes liquids in a controlled, circular movement. Orbital circular paths with a diameter of 3 mm and up to 3,000 rpm: Generates excellent mixing performance, even for challenging samples. The ThermoMixer C provides enough mixing power to handle also challenging mixing tasks. Most samples are efficiently mixed within less than a minute independent of vessel geometry or sample properties.

Using different vessel formats?

A wide varity of Eppendorf SmartBlocks are available for the Eppendorf ThermoMixer C. These thermoblocks offer you a broad flexibility for use of nearly all common vessel and plate formats.

• Fast and simple block exchange due to Eppendorf QuickRelease
• Optimized block design guarantees maximum temperature transfer to the sample
• Individually sensor‐controlled Eppendorf SmartBlocks allow for block‐specific calibration

Tired of condensation in your tubes?

We combined the Eppendorf ThermoMixer with the PCR cycler approach of a heated lid and generated the Eppendorf ThermoTop^®. The outstanding Eppendorf condens.protect technology reliably prevents condensation within the tube lid – sample concentrations are consistent for the incubation time.
In addition, the temperature homogeneity is further improved. Get optimal sample reaction conditions to produce optimal results.

• Efficient and reliable condensation prevention on tube lids for safe sample heating
• Get constant reaction conditions for optimal enzymatic performance within your sample
• Wireless connection with automatic recognition and operation for user-friendly handling

Missing a second temperature for an incubation at 37 °C or 95 °C at your Eppendorf ThermoMixer?

The Eppendorf SmartExtender offers a comfortable incubation tool which can easily be used as an add-on to your existing Eppendorf SmartBlocks and the Eppendorf ThermoMixer C/Fx as well as Eppendorf ThermoStat C. Up to 12 vessels (1.5 mL) can be heated up for a higher throughput and higher flexibility in your lab. The independent heating function for the second temperature enables a parallel usage of an Eppendorf SmartBlock and the SmartExtender. The Eppendorf SmartBlock at the center can still be used for heating, cooling, and mixing.

Annoyed by uncomfortable handling?

Ergonomics is far beyond the »ergonomically designed chair«. Eppendorf started to optimize the laboratory devices regarding ergonomics already in the early 1970s.
In 2003, we started the PhysioCare Concept, focusing on ergonomic liquid handling devices like our pipettes.
Nowadays, the Eppendorf PhysioCare Concept is broaden up to include further laboratory products as a holistic solution to harmonize the workflow in your laboratory with your health and well-being, e.g. for the Eppendorf ThermoMixer:
• Eppendorf QuickRelease for easy and fast block exchange
• Insulated SmartBlock for safe gripping / no burning of fingers
• Direct keys for convenient handling
• Small footprint to enable position in direct arm reach at your bench
• Standardized »user-interface concept« for intuitive handling of devices

Further information about the Eppendorf PhysioCare Concept:
www.eppendorf.com/physiocare/

Struggling with paper-based documentation?

The eLabJournal Electronic Lab Notebook offers an intuitive and flexible solution to document research and track research data like workflow processes where the Eppendorf ThermoMixer is involved. Improve efficiency when documenting, organizing, searching, and archiving collected data. With the free eLabJournal add-ons, you can extend the functionality of eLabJournal to a fully integrated Laboratory Information Management System.

Start a free 30-day trial!
Visit www.eLabJournal.com

Efficient lab and device management with VisioNize^® Lab Suite

Are you interested in monitoring your lab devices and receiving notifications e.g., for device alarms? A digital, connected lab offers even more.

Gain access to a modular range of digital services and choose what works for your lab. VisioNize Lab Suite offers everything you need as a Lab Manager or Scientist to get started to digitally manage your lab for increased sample security, compliance needs and maintenance management.

Chart your own course to digital lab excellence! Find out more

Disposal of packaging

The packaging of the mixer contains different materials, this includes cardboard, a plastic dust cover, and some foam parts. Recycling of materials becomes more and more important every day: Are you aware that nearly all cardboard material is recycled in Europe? Our mixer packaging cardboard material consists of ca. 60 % recycling material. Please support the global sustainability initiative of recycling valuable raw material by also collecting the thermomixer cardboard packaging material and disposing of it in the appropriate collection container at your organization. In respect to the plastic dust cover made of LD-PE and the foam parts, we recommend to select a dedicated recycling partner where PE material can be recycled. We suggest you contact your local waste hauler or facility management team to understand the available recycling options for your organization.

Disposal of instrument
Our mixers last for many years, but if they need to be replaced, we kindly ask you to fulfill local requirements for disposal of these instruments. We strongly recommend a certified local recycling partner with experience in instruments with electronics. Keeping it "local" reduces the impact of transportation, and the "certified" aspect is recommended due to the safe and sustainable removal of specific parts.

Decontamination
This piece of equipment was used in a laboratory and/or was used to handle biological samples. Please keep in mind to adequately decontaminate the equipment which needs to be disposed. Check local requirements. For more information, get in contact with your local biosafety officer and/or waste officer. Check if your local recycling partner has special instructions and/or documentation requirements. You may also use the Eppendorf decontamination form sheet as guidance.

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Specifications	Eppendorf ThermoMixer^® C

ACT label	yes
Sample capacity	All common vessels and plate formats from 5 µL to 50 mL
Product type	ThermoMixer
Timer	5 sec to 99:30 h, continuous
Interfaces	USB interface
Power supply	220 – 240 V, 50 – 60 Hz
Max. power consumption	200 W
Dimensions (W × D × H)	20,6 × 30,4 × 13,6 cm / 8,1 × 12,0 × 5,4 in
Product weight	6,3 kg / 13,9 lb
Max. speed	3,000 rpm¹⁾
Temperature range	Min: 15 °C below RT, max: 100 °C¹⁾
Mixing frequency	300 – 3,000 rpm¹⁾
Mixing and vortexing radius	1.5 mm
Temperature settings	1 °C / 100 °C
Mixing orbit	3 mm
Temperature accuracy	Max. ±0.5 °C at 20 – 45 °C

Eppendorf ThermoMixer^®
Heating rate	Max. 7 °C/min (when using SmartBlock plates)¹⁾
Cooling rate	Max. 2.5 °C/min between 100 °C and RT

1)depending on SmartBlock used

Downloads: Eppendorf ThermoMixer^® C

Brochure

Die perfekte Mischung

Eppendorf Temperier- und Mischgeräte

PDF 2.1MB

German

Flyer

Take Full Advantage of Versatility

Missing a second incubation temperature for your Eppendorf ThermoMixer^®?

Eppendorf Temperature Control and Mixing Instruments

PDF 2.1MB

English

Flyer

Vorteil der Vielseitigkeit

Benötigen Sie eine zweite Temperatur für Ihren Eppendorf ThermoMixer^®?

PDF .4MB

German

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Eppendorf ThermoMixer® C