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BioFlo® 510
BioCommand Setup
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Cell Culture Impellers
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Product Information
SIP benchtop reactors designed to meet the needs of R&D through production.You will find additional download material at the bottom of this page
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Catalog no.
0082140299
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Product Information
Applications
Features
The BioFlo 510 is a compact sterilizable-in-place fermentation system ideal for pilot to small scale production processes. The modular design features a wide variety of standard options allowing this system to be flexible enough to meet most process requirements.
Gas flow
• Various combinations of one, two, three or four TMFCs:
0.06 – 3 SLPM
0.3 – 15 SLPM
0.6 – 32 SLPM
1 – 64 SLPM
• Overlay (valve only)
Exhaust line
• Exhaust condenser
• Manual or automatic pressure control
Impellers
• Rushton-type – Used commonly for robust cell lines such as bacteria, yeasts, and algae, where maximum OTR is desired. Provided as standard on BioFlo 510 fermentors
• Pitched-blade – Commonly used with mammalian, insect or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial and radial mixing.
• Marine – Commonly used with mammalian, insect, or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial mixing
Sensors
• Single or redundant pH/DO
• Redox
• Foam/level
Addition and sampling
• Resterilizable sampling valve
• Resterilizable addition valves (4 max)
• Resterilizable addition/harvest valve with dip tube (2 max)
• 1.5 in sanitary fitting 7-port septum
• Addition vessels (glass/stainless steel)
• Sterile sampling assembly
Validation
• Basic Package
• Basic Plus Package
• Enhanced Package
Utility regulator & pre-filter kits
• Process air pre-filter/regulator kit
• Instrument air pre-filter/regulator kit
• Water pre-filter/regulator kit
• Process steam regulator kit
• Utility steam pre-filter/regulator kit
• Utility connection kit
Additional options
• Sprayballs for clean-in-place of vessel
• External variable-speed pumps
• External scales
• Spare parts kits
• Preventive maintenance kits
• Mobile table
• System passivation
• Glycol/chiller heat exchanger
Gas flow
• Various combinations of one, two, three or four TMFCs:
0.06 – 3 SLPM
0.3 – 15 SLPM
0.6 – 32 SLPM
1 – 64 SLPM
• Overlay (valve only)
Exhaust line
• Exhaust condenser
• Manual or automatic pressure control
Impellers
• Rushton-type – Used commonly for robust cell lines such as bacteria, yeasts, and algae, where maximum OTR is desired. Provided as standard on BioFlo 510 fermentors
• Pitched-blade – Commonly used with mammalian, insect or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial and radial mixing.
• Marine – Commonly used with mammalian, insect, or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial mixing
Sensors
• Single or redundant pH/DO
• Redox
• Foam/level
Addition and sampling
• Resterilizable sampling valve
• Resterilizable addition valves (4 max)
• Resterilizable addition/harvest valve with dip tube (2 max)
• 1.5 in sanitary fitting 7-port septum
• Addition vessels (glass/stainless steel)
• Sterile sampling assembly
Validation
• Basic Package
• Basic Plus Package
• Enhanced Package
Utility regulator & pre-filter kits
• Process air pre-filter/regulator kit
• Instrument air pre-filter/regulator kit
• Water pre-filter/regulator kit
• Process steam regulator kit
• Utility steam pre-filter/regulator kit
• Utility connection kit
Additional options
• Sprayballs for clean-in-place of vessel
• External variable-speed pumps
• External scales
• Spare parts kits
• Preventive maintenance kits
• Mobile table
• System passivation
• Glycol/chiller heat exchanger
- Laboratory- and pilot-scale fermentation of aerobic and anaerobic bacteria, yeasts, and fungi
- Laboratory- and pilot-scale cell culture of mammalian, insect, and human cell lines
- Special applications such as stem cell culture, vaccine, monoclonal antibody or biofuel/biopolymer production
- Suitable for batch, fed-batch, and continuous/perfusion processes
- RPC (Reactor Process Control) software
- 32.0 L working volume stainless-steel electropolished vessels with 2:1 aspect ratios
- Integrated load cell
- 3-fixed speed peristaltic pumps for the additions, harvest and pH control
- Benchtop or Mobile option
- Includes Rushton-type impellers with pitched-blade and marine blade option
- Industrial touchscreen interface