Gain Better Bioprocess Data with Less Effort:
You often need to sample your culture during the bioprocess, not just at the end. These samples help you monitor growth, product formation, and nutrient consumption. This way, you can identify interdependencies and take action at predefined times or specific events, like DO rising after carbon source depletion. The Bioprocess Autosampler from Eppendorf provides this solution to you. Whether you are working in cell culture or fermentation, in early R&D or process development, and using single-use or glass bioreactors, this system covers it all. The Bioprocess Autosampler can handle sampling and bolus addition at short, regular intervals, helping you gain complete datasets and automate bioprocess control.
The advantages of automated sampling:
Short and regular sampling intervals help obtaining strong datasets. Regular measurement of process parameters, the cells' status, and the concentration and quality of the product is the basis for a comprehensive view on the process. Such information is indispensable for process optimization.
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Bioprocess Autosampler
Bioprocess Autosampler dual head system, 4x DASbox, bottles side, front view, cropped
Bioprocess Autosampler:
Modular autosampling solution for small and bench scale bioprocess systems
Modular autosampling solution for small and bench scale bioprocess systems
Bioprocess Autosampler connection of vessel to multi port module 3
Bioprocess Autosampler sample storage 1
Efficient sampling from bioreactors of different sizes. Different sample sizes with aseptic operation and low dead volume.
Bioprocess Autosampler tool stations and multi port modules, angled bottom view
Bioprocess Autosampler dual head system, 2x DASbox, front view 1
Bioprocess Autosampler dual head system, 2x DASGIP Parallel System, front view 1
Gain Better Bioprocess Data with Less Effort
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Product Information
The Bioprocess Autosampler takes samples from multiple bioreactors and stores them tempered for later analysis. It is compatible with glass and single-use bioreactors operated with a DASbox® Mini Bioreactor System, DASGIP® Parallel Bioreactor System, SciVario® twin or BioFlo® 320 bioreactor control system.You will find additional download material at the bottom of this page
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Product Information
Applications
Features
Product Information
Automated sampling
• Facilitates sampling 24/7 in regular, short intervals
• Time is freed up for other tasks
• Automated sample storage reduces risk for human error
Sampling Procedure
• The Bioprocess Autosampler holds one sampling port per bioreactor
• Tubing connects the sampling port with a dip tube in the bioreactor
• Sampling ports harbor a septum, which preserves the sterility of the bioreactor
• For sampling, a needle connected to a syringe is automatically inserted into the port, pinching through the septum
• The sample is transferred to a sampling vial by pinching through a septum in the vial lid
Compatible Small Scale Bioprocess Control Systems
The Bioprocess Autosampler can be installed with new as well as retrofitted to existing small scale bioreactor control systems.
DASbox® Mini Bioreactor System
• Autosampling of up to 16 bioreactors
• Compatible with glass and single-use bioreactors
• Working volume: 60 – 250 mL
DASGIP® Parallel Bioreactor System
• Autosampling of up to 16 bioreactors
• Compatible with glass and single-use bioreactors
• Working volume: 200 mL – 1.8 L
Compatible Bench Scale Bioprocess Control Systems
The Bioprocess Autosampler can be installed with new as well as retrofitted to existing bench scale bioreactor control systems.
SciVario® twin
• Autosampling of up to 8 bioreactors
• Compatible with glass and single-use bioreactors
• Working volume: 200 mL - 10 L
BioFlo® 320
• Autosampling of up to 4 bioreactors
• Compatible with glass and single-use bioreactors
• Working volume: 320 mL – 10.5 L
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Applications
- Research and development in microbiology and cell culture
- Suitable for aerobic and anaerobic bacteria and yeasts, as well as mammalian cell lines
- Suitable for small scale and bench scale bioprocess control systems
- Suitable for batch, fed-batch, and continuous processes
Features
- Aseptic operation without the use of a laminar flow cabinet
- Compatible with differently-sized glass and BioBLU® Single-Use Bioreactors with working volumes of 60 mL to 10 L
- Suitable for 1.5 mL and 10 mL sample vials, up to 648 samples can be stored
- Enables regular sampling 24/7
- Sample storage between 4 and 40 °C.
- Sanitation procedure using ethanol is similar to procedures, usually applied when sampling manually
- Low dead volume minimizes the reduction of culture volume
- Modular design that facilitates expansion of the number of bioreactors to be sampled and retrofitting of existing bioprocess systems
- Bolus addition is available as an option, either at a pre-defined time or event-based through the scripting feature in the software
- Control of the Bioprocess Autosampler is integrated in DASware® control bioprocess software
