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Fibra-Cel® Disks
Product Information
Fibra-Cel disks are a proven support system used to increase yields of suspension and anchorage-dependent cultures. Fibra-Cel is also available for use in disposable bags, shake flasks and other bioreactor systems.You will find additional download material at the bottom of this page
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Product Information
Applications
Features
Product Information
Fibra-Cel is a solid support growth matrix for mammalian, animal, and insect cells, used predominantly for production of secreted products such as recombinant proteins and viruses. Fibra-Cel enables sustained long-term periods of high-density growth in perfusion, without danger of clogging; and eliminates the need for cell filtration to separate cells from the end product.
HEK-293 cells grown on Fibra-Cel disk at day 7 of the growth cycle
High-resolution micrograph of a Fibra‑Cel disk indicating the polyester mesh with polypropylene support
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Applications
- Hybridoma: DA4-4, 123A, 127A, GAMMA, 67-9-B
- Anchorage-Dependent: 3T3, COS, Human Osteosarcoma, MRC-5, BHK, VERO, CHO, rCHO-tPA, rCHO - Hep B Surface Antigen, HEK 293, rHEK 293, rC127 - Hep B Surface Antigen, Normal Human Fibroblasts, Stroma, Hepatocytes
- Insect: Tn-368, SF9, rSF9, Hi-5
Features
- Low pressure drop across the bed of Fibra-Cel minimizes the variability and maintains a global viability of cells over the entire bed
- High surface-to-volume ratios increases the total biomass that can be maintained in the bioreactor greatly enhancing production of cellular products
- Entrapped cells are shielded from the turbulence and are less susceptible to shear forces from impeller blades and sparger gas bubbles
- Higher mass transfer of nutrients and oxygen versus standard microcarrier systems
